I know you aren't supposed to delete mods mid playthrough (though mesh files I've heard are okay-ish if you need to), so I was wondering if there was any possible solution to this issue. I disabled it and loaded an older save without it enabled, and it worked fine. So I looked up CTD on game loading, and found out another mod of mine seemed to be the culprit for some people, Homemaker. I tried reinstalling the exact same way another time or two (selecting Replace), but it wasn't going to happen.
I tried a few times on the more recent saves, thinking it might have been a fluke, but it wasn't. However, after rearranging the plugins to the stable state they were in before…I couldn't load the game. So I reinstalled the mod in the same way I'd had it installed before (SFAIK). However, I'd been having an issue with the Bow's sights not actually working right, and found out that See Through Scopes had a built in patch for it that I hadn't enabled (I installed LStrings halfway through my early playthrough, only around 15 hours in). The only real issue with it SFAIK is balancing, which I felt was fine since you can't really use VATS with it. The only thing I don't have patched in the game (since there isn't one available) is LStrings Bow mod.
Up until a few minutes ago, everything was working fine. So I am currently playing a pretty heavily modded version of FO4 based around Horizon (1.8).